.list-unstyled.mb-0 a {
    /*opacity: 0.7;*/
    color: #fff;
}
.widtd148{
    width: 148px !important;
}
.box{
    position: relative;
}
.tikcus {
    position: absolute;
    left: 23px;
    margin-top: 9px;
}
.img-content-sec .inner-div img {
    position: absolute;
    margin-top: 10px;
}
.btn-orange img {
    vertical-align: initial;
    margin-left: 15px;
}
.studytem  tr:last-child{
    border-bottom: none !important;
}

.disclosures_cardItem {
    position: relative;
}
span.fpo {
    position: absolute;
    top: 5%;
    left: 31%;
    font-size: 77px;
    color: #EF5CF4;
    font-weight: 700;
}

/* faq section */


.container-faq {
    display: flex;
    max-width: 90%;
    margin: 40px auto;
    gap: 50px;
    padding: 0 20px;
}

/* LEFT SIDEBAR */
.sidebar-faq {
    width: 30%;
}

.sidebar-faq ul {
    list-style: none;
    margin: 0;
    padding: 0;
}

.sidebar-faq li {
    padding: 14px 18px;
    margin-bottom: 10px;
    border-radius: 8px;
    color: #1E293B;
    font-size: 18px;
    font-weight: 600;
    cursor: pointer;
    transition: background 0.25s, color 0.25s;
}

.sidebar-faq li:hover {
    background: #f4f4f4;
}

.sidebar-faq li.active {
    background: #ff6f1e; /* orange */
    color: #fff;
    border-color: #ff6f1e;
}

/* FAQ CONTENT */
.faq-container {
    flex: 1;
    background: #ffff;
    padding: 40px;
}

/* Hide inactive tab content */
.tab-content1 {
    display: none;
}

.tab-content1.active {
    display: block;
}

.accordion-item {
    background: #fff;
    margin-bottom: 14px;
    overflow: hidden;
    border-bottom: 1px solid #ddd;
}
.accordion-item:last-child{
    border: none !important;
    border-bottom: none !important;
}
.accordion-header {
    padding: 20px 0px;
    font-size: 23px;
    font-weight: 600;
    cursor: pointer;
    position: relative;
}

.accordion-header::after {
    content: "";
    position: absolute;
    right: 20px;
    top: 50%;
    width: 18px;
    height: 18px;
    background-size: contain;
    background-repeat: no-repeat;
    transform: translateY(-50%) rotate(0deg);
    transition: 0.25s ease;
    background-image: url("data:image/svg+xml;utf8,<svg viewBox='0 0 24 24' fill='none' stroke='%23222' stroke-width='2' stroke-linecap='round' stroke-linejoin='round' xmlns='http://www.w3.org/2000/svg'><polyline points='6 9 12 15 18 9'></polyline></svg>");
}

/* When open (rotate arrow up) */
.accordion-item.active .accordion-header::after {
    transform: translateY(-50%) rotate(180deg);
}


/*.accordion-item.active .accordion-header::after {
    content: "−";
}*/

.accordion-body {
    display: none;
    padding: 0 0px 20px;
    font-size: 18px;
    color: #1E293B;
    font-weight: 400;
    line-height: 29px;
}

/* faq second section */

/* Section Layout */
.faq-section {
  padding: 60px 40px;
  background: #ffffff;
}

.faq-container2 {
  display: flex;
  justify-content: space-between;
  align-items: center;
  max-width: 90%;
  margin: auto;
}

/* Left side text */
.faq-label {
  color: #f47c2f;
  font-weight: bold;
  letter-spacing: 1px;
  font-size: 14px;
}

.faq-title {
    font-size: 32px;
    margin: 10px 0;
    color: #002C77;
    font-weight: 700;
}

.faq-desc {
    max-width: 450px;
    color: #314657;
    line-height: 29px;
    font-size: 15px;
}

/* Search box */
.search-box {
  background: #f3f3f3;
  padding: 12px 18px;
  border-radius: 8px;
  display: flex;
  align-items: center;
  width: 260px;
}

.search-icon {
  font-size: 16px;
  margin-right: 10px;
  color: #444;
}

.search-box input {
  border: none;
  background: transparent;
  width: 100%;
  font-size: 15px;
  outline: none;
}

/* dosing page css */

.dosingcss .inner-img{
    text-align: right;
}

.dosingcss .inner-img img{
    width: 82%;
    margin: 0 auto;
}

.container-card {
    display: flex;
    gap: 20px;
    justify-content: space-between;
}

.card {
    display: grid;
    grid-template-columns: 40% 57%;
    background: white;
    border-radius: 15px;
    gap: 15px;
    max-width: 48%;
}

.card-section {
    background: #ffffff;
    padding: 20px;
    margin-top: 0;
    margin-bottom: 0;
    order:2;
    border-radius: 20px;
}

.card-section h3 {
    font-size: 20px;
    color: #003f91;
    margin-top: 0;
    font-weight: bold;
}

.card-section ul {
    margin-top: 10px;
    padding-left: 20px;
    font-size: 16px;
}

.image-section {
    background: #003f91;
    border-top-left-radius: 10px;
    border-bottom-left-radius: 10px;
    display: flex;
    align-items: center;
    justify-content: center;
    order: 1;
}

.image-section img {
    width: 90%;
    height: auto;
}

section.img-content-sec.dosing-sec.dosingcss {
    padding-bottom: 55px;
    margin-bottom: 48px;
}

@media (max-width: 768px) {
    .container-card{
        display: block;
    }
    .card {
        grid-template-columns: 100%;
        max-width: 100%;  /* optional */
        margin-bottom: 30px;
    }
    .image-section{
        border-top-right-radius: 10px;
        border-bottom-left-radius: 0;
        border-bottom-right-radius: 0;
        border-top-left-radius: 10px;
    }
}

/* access and support page css */

.card-access {
    background: #ffffff;
    border-radius: 12px;
    overflow: hidden;
    box-shadow: 0 4px 10px rgba(0,0,0,0.1);
}

.header-access {
    background: #004890;
    color: white;
    padding: 20px;
    display: flex;
    align-items: center;
}

.logo-access {
    width: 45px;
    height: 45px;
    margin-right: 15px;
}

.title-access h2 {
    margin: 0;
    font-size: 30px;
    font-weight: 800;
    color: #fff;
}

.title-access p {
    margin: 0;
    font-size: 24px;
    opacity: 0.9;
    line-height: 1;
    font-weight: 100;
}

.info-bar-access {
    background: #f25a2b;
    color: white;
    padding: 10px;
    display: flex;
    gap: 25%;
    font-size: 14px;
}

.details-access {
    padding: 15px 20px;
}
.details-access p {
    line-height: 25px;
    font-size: 15px;
    font-weight: 400;
    color: #314657;
    margin-bottom: 0px;
}

.banner-content-cus {
    font-size: 31px;
    line-height: 32px;
    font-weight: 700;
    color: #002C77;
    line-height: 30px;
}
.right-text p {
    color: #314657;
}

p.bottom-spancus {
    text-align: center;
    font-size: 20px;
    color: #314657;
    padding-top: 40px;
}
p.access-content {
    color: #314657;
    font-size: 22px;
    line-height: 31px;
}
/* access third section css */
.card-section-retail {
    display: flex;
    gap: 20px;
}
.section-title-retail {
    color: #e27030;
    font-size: 16px;
    font-weight: bold;
}

.main-title-retail {
    font-size: 32px;
    line-height: 1.3;
    margin-top: 10px;
}

.sub-text-retail {
    margin-top: 10px;
    font-size: 18px;
    color: #314657;
}

.cards-retail {
    display: flex;
    gap: 20px;
    margin-top: 30px;
    flex-wrap: wrap;
}

.card-retail {
    background: #003D73;
    color: white;
    padding: 30px 20px;
    border-radius: 10px;
    flex: 1;
    min-width: 250px;
}
.card-retail {
    display: flex;
    gap: 15%;
    align-items: center;
    justify-content: space-between;
}

.card-retail h2 {
    font-size: 18px;
    margin-bottom: 10px;
    color: #ffffff;
}

.card-retail a {
    color: #fff;
    font-weight: bold;
    text-decoration: none;
}
span.numberf {
    display: inline-flex;
}
.support-link-retail {
    color: #e27030;
    font-weight: bold;
    margin-top: 30px;
}

.footer-note-retail {
    margin-top: 10px;
    font-size: 13px;
    color: #666;
}

.pills-img-retail {
    width: 230px;
    position: absolute;
    top: 40px;
    right: 0;
}
.pills-image-retail {
    /* position: absolute; */
    /* top: 40px; */
    right: 0;
    width: 90%;
}
.content-part img {
    width: 17px;
    margin-right: 10px;
}
.icon-retail {
    width: 65px;
    margin-bottom: 12px;
}
.right-section {
    width: 44%;
}
.top-sectionrap {
    display: flex;
    justify-content: space-around;
    gap: 8%;
    padding-bottom: 25px;
}
.left-section {
    width: 57%;
}
span.semiblod {
    font-weight: 700;
    color: #314657;
    font-size: 18px;
    font-style: italic;
}
.left-section h2 {
    font-weight: 700;
    color: #002C77;
    font-size: 30px;
}

/* safety page css */
:root{
    --blue:#0b57a4;     /* header blue */
    --muted:#6b7280;    /* muted footnote text */
    --table-bg:#ffffff;
    --border:#e6eef9;
    --radius:12px;
    --gap:18px;
    --cell-padding:18px 20px;
  }
.card-safety{
    width:100%;
    background:var(--table-bg);
    box-sizing:border-box;
  }

  .sec-safety .title {
    font-size: 29px;
    font-weight: 700;
    margin: 0 0 14px 0;
    color: #002C77;
}

  .sec-safety table{
    width:100%;
    border-collapse:collapse;
    font-size:15px;
    background:transparent;
    table-layout:fixed;
  }

  .sec-safety thead th{
    background:#002C77;
    color:white;
    text-align:left;
    padding:16px 18px;
    font-weight:600;
    vertical-align:middle;
  }

 .sec-safety thead th.center{
    text-align:center;
  }

  .sec-safety tbody tr{
    border: 1px solid var(--border);
  }
.sec-safety tbody tr:last-child td:first-child {
    border-bottom-left-radius: 12px;  /* change size as needed */
    overflow: hidden;
}
.sec-safety tbody tr:last-child td:last-child {
    border-bottom-right-radius: 12px;
}

.sec-safety tbody td{
padding: var(--cell-padding);
vertical-align:middle;
background:transparent;
}

  .sec-safety td:first-child{
    width:50%;
    font-weight:500;
  }

.sec-safety td.center {
    text-align: center;
    width: 25%;
    font-weight: 600;
    border-left: 1px solid #ddd;
}

  /* make header cells have rounded corners */
  .sec-safety thead th:first-child{ border-top-left-radius:10px; }
 .sec-safety thead th:last-child{ border-top-right-radius:10px; }
 .sec-safety tbody td:last-child{ border-bottom-right-radius:10px; }

  /* subtle zebra on rows (like the image has white rows but we keep it clean) */
  .sec-safety tbody tr:nth-child(even) td{ background: rgba(11,87,164,0.02); }

  .footnotes-safety{
    margin-top:14px;
    font-size:13px;
    color:var(--muted);
    line-height:1.45;
  }

  .footnotes-safety p{ margin:6px 0; }

  .small-note-safety{
    margin-top:10px;
    font-size:12px;
    color:#475569;
  }

  @media (max-width:640px){
    .card-safety{ padding:14px; }
    thead th, tbody td{ padding:10px; font-size:14px; }
    td:first-child{ width:52%; }
  }

  /* exploartory subgroup analysis page css */

   :root {
    --blue-dark: #003a78;
    --blue-light: #e7f3ff;
    --btn-orange: #ff7f32;
    --text-dark: #0f172a;
    --radius: 14px;
  }

  .wrapper-exp {
    max-width: 780px;
    width: 100%;
  }

  h2 {
    color: var(--text-dark);
    font-size: 28px;
    font-weight: 700;
    margin-bottom: 18px;
  }

  .card-exp {
    background: var(--blue-dark);
    color: #fff;
    padding: 28px;
    border-radius: var(--radius);
    box-sizing: border-box;
  }

  .card-title-exp {
    font-size: 20px;
    font-weight: 600;
    margin-bottom: 14px;
  }

  hr {
    border: none;
    border-top: 1px solid rgba(255,255,255,0.35);
    margin: 10px 0 18px;
  }

  .content-exp {
    font-size: 15px;
    line-height: 1.55;
    margin-bottom: 22px;
  }
.wrapper-exp h2 {
    color: #002C77;
}
  @media (max-width: 600px) {
    h2 { font-size: 22px; }
    .card-exp { padding: 20px; }
  }

h2 {
    font-size: 26px;
    font-weight: 700;
    color: #0b3c82;
    margin-bottom: 30px;
}

  /* Chart Box */
.chart-box {
    border-radius: 8px;
    padding: 25px;
    position: relative;
}
.chart-box img {
    width: 75% !important;
}
  /* Footer Notes */
.footer {
    font-size: 13px;
    margin-top: 20px;
    color: #495d77;
    line-height: 1.45;
}
p.afterimag {
    text-align: center;
    font-size: 18px;
    font-weight: 600;
    color: #314657;
    font-style: italic;
}
p.bottmtext {
    font-size: 18px;
    color: #314657;
}
p.bptext{
    color: #314657;
}
h2.headingtext {
    font-size: 24px;
    font-weight: 700;
    color: #002C77;
}
section.sos-sec {
    padding-top: 45px !important;
}

/* third section css */

.title-exp-bottom {
    font-size: 27px;
    font-weight: 700;
    color: #002C77;
    max-width: 1010px;
    margin-bottom: 10px;
}

.subtitle-exp-bottom {
    margin-top: 1px;
    font-size: 23px;
    color: #314657;
}

.cards-exp-bottom {
    display: flex;
    gap: 20px;
    margin-top: 25px;
    flex-wrap: wrap;
    align-items: center;
    justify-content: center;
}

.card-exp-bottom {
    width: 400px;
    background:  #002D78;
    border-radius: 12px;
    padding: 30px 0px;
    color: white;
}
.percent-exp-bottom, .text-row-exp-bottom{
    padding-left: 30px;
}
.percent-exp-bottom {
    /* Gradient text */
    background: linear-gradient(135deg, #002D78, #3C83FF);
}
span.percentage-card {
    color: #fff !important;
    font-size: 35px;
    font-weight: 700;
    margin-bottom: 12px;
}
.text-row-exp-bottom {
    display: flex;
    align-items: center;
    gap: 20px;
    padding-top: 13px;
}

.icon-exp-bottom {
    width: 28px;
    height: 28px;
    display: flex;
    align-items: center;
    justify-content: center;
}

.desc-exp-bottom {
    font-size: 16px;
    line-height: 1.3em;
    margin-bottom: 0px;
    margin-top: 10px;
}
.icon-exp-bottom img {
    width: 38px;
}

.note-exp-bottom {
    background: #ffffff;
    padding: 18px;
    margin-top: 30px;
    border-radius: 8px;
    text-align: center;
    font-size: 21px;
    color: #002C77;
    font-weight: 700;
    border: 1px solid #e0e0e0;
    max-width: 825px;
    margin: 30px auto;
}
.footer-exp-bottom {
    margin-top: 20px;
    font-size: 16px;
    text-align: center;
    color: #314657;
    font-style: italic;
}
p.footer2-exp-bottom {
    padding-top: 37px;
    color: #314657;
}

/* Primary endpoint page css */

.orange-text{
    letter-spacing: 1px;
    color: #EF5F17;
    font-weight: 800;
}

.wrapper-primary-ent h2 {
    font-size: 30px;
    font-weight: 700;
}
p.normaltext {
    color: #314657;
}

/* second section css */
.secondary-endpoint-can {
    display: flex;
    gap: 30px;
}
.wrap-secw{
    max-width:var(--container-max);
    margin:36px auto;
    padding:18px 24px;
  }

  /* Heading */
  .heading-secw {
    font-size: 28px;
    font-weight: 700;
    color: #002C77;
    margin: 0 0 14px 0;
    letter-spacing: 0.1px;
}
 /* .heading-secw sup{
    font-size:12px;
    vertical-align:super;
    margin-left:6px;
    color:var(--heading-color);
    font-weight:600;
  }*/

  /* List */
  .endpoints-secw{
    margin:0;
    padding-left:18px; /* room for custom bullets */
    max-width:720px;
  }

  .endpoints-secw li{
    position:relative;
    padding-left:18px;
    margin:10px 0;
    line-height:1.45;
    font-size:15px;
    color:#314657;
    /* ensure bullets align with shorter first line */
    word-break:break-word;
  }

  /* custom circular bullet to match screenshot */
  .endpoints-secw li::before{
    content:"";
    position:absolute;
    left:0;
    top:8px; /* vertically center-ish */
    width:8px;
    height:8px;
    border-radius:50%;
    background:var(--bullet-color);
    box-shadow:0 0 0 2px rgba(125,155,184,0.06);
  }

  /* slightly lighter color for numbers/abbreviations if desired */
  .muted-secw{
    color:#6b7680;
  }

  /* responsive tweaks */
  @media (max-width:420px){
    .wrap-secw{ padding:14px; margin:18px; }
    .heading-secw{ font-size:18px; }
    .endpoints-secw li{ font-size:14px; margin:8px 0; }
    .endpoints-secw li::before{ top:7px; }
  }
  /* section third */

.section-endt {
    max-width: 1200px;
    margin: auto;
    padding: 40px;
}

.title-endt {
    font-size: 26px;
    font-weight: 700;
    color: #093c7c;
    margin-bottom: 30px;
}

.cards-endt {
    display: flex;
    gap: 24px;
    flex-wrap: wrap;
}

.card-endt {
    background: white;
    border-radius: 14px;
    width: 31%;
    padding: 22px;
    box-shadow: 0 4px 10px rgba(0,0,0,0.08);
}

.tag-endt {
    display: inline-block;
    padding: 6px 14px;
    font-size: 14px;
    font-weight: 700;
    border-radius: 8px;
    margin-bottom: 14px;
    color: white;
}

.tag-red-endt {
    background: #EF5F17;
}
.icon-endt img {
    width: 40px !important;
}
.value-endt {
    margin-top: 10px;
}
.tag-red2-endt { background: #EB5A3E; }
.tag-orange-endt { background: #F7A33A; }

.blue-box-endt {
    background: #073d8d;
    border-radius: 12px;
    padding: 20px;
    display: flex;
    align-items: center;
    gap: 18px;
}

/*.icon-endt {
    width: 40px;
    height: 40px;
}*/

.value-endt {
    font-size: 36px;
    font-weight: 700;
    color: white;
    line-height: 20px;
}

.value-endt span {
    font-size: 18px;
    font-weight: 300;
}

.subtext-endt {
    margin: 14px 0 8px;
    font-size: 14px;
    color: #3a4a60;
}

.bar-endt {
    height: 8px;
    background: #e1e5eb;
    border-radius: 50px;
    margin-bottom: 12px;
    overflow: hidden;
}

.fill-endt {
    height: 100%;
    background: #3a4a60;
    border-radius: 50px;
}

.desc-endt {
    font-size: 14px;
    color: #4a5566;
    line-height: 1.35;
}

.footer-endt {
    font-size: 12px;
    color: #4a5566;
    margin-top: 40px;
    line-height: 1.4;
}

.bottom-note-endt {
    font-size: 14px;
    color: #0948a0;
    font-weight: 600;
    margin-top: 30px;
}
.title-box {
    font-size: 28px;
    font-weight: 700;
    color: #002C77;
    padding: 12px 15px;
    width: fit-content; 
}
.three-col-box.three2-col-box img {
    width: 120px !important;
    top: 20% !important;
    right: 20px;
}
.three-col-box.second-three2-col-box img {
    width: 80% !important;
}
.inner-boxes.position-relative.h-100.three2-col-box, .inner-boxes.position-relative.h-100.second-three2-col-box {
    min-height: auto !important;
}

.bp-lowering-section {
    max-width: 1200px;
    margin: 20px auto;
    padding: 10px 0;
    font-family: "Arial", sans-serif;
}

.bp-text {
    color: #0a3c80;        /* dark blue like screenshot */
    font-size: 20px;
    line-height: 1.5;
    margin-bottom: 8px;
}

.bp-note {
    color: #6f7d90;        /* light grey-blue */
    font-size: 14px;
    line-height: 1.4;
}

a.back-to-top {
    position: fixed !important;
    bottom: 20px;
    right: 20px;
    z-index: 99999999;
    display: none; /* start hidden */
    cursor: pointer;
}
a.back-to-top img {
    width: 80px;
    height: auto;
}

@media(max-width:1200px) {
    .container-faq{
        max-width: 100%;
        gap: 20px;
    }
    .sidebar-faq li{font-size: 16px;}
    .faq-container{padding: 20px;}

    .accordion-header{font-size: 18px;}
    .accordion-body{    font-size: 15px;padding: 0;}
    .accordion-item{margin-bottom:0;}
    .card-section{padding: 15px;}

    .container-card{
        max-width: 800px;
        margin: 0 auto;
        flex-direction: column;
        align-items: center;
    }
    .container-card .card{
            max-width: 100%;
    }

}

@media(max-width:1024px) {
    .cards-endt{justify-content: center;}
    .card-endt{width: 48%;}
    .section-endt{
        padding-left: 0;
        padding-right: 0;
    }
}

@media(max-width:992px) {
    .secondary-endpoint-can{
        flex-direction: column;
    }
    .wrap-secw{
        margin: 0;
    }
}

@media(max-width:767.98px) {
    .card-endt{width: 100%;}
    .container-faq{
        flex-direction: column;
    }
    .sidebar-faq {
        width: 100%;
    }
    .sidebar-faq li{
        padding: 10px;
    margin-bottom: 5px;
    }

}